With its consistent, practical organization and succinct bulleted format, Atlas of Head and Neck Pathology, 4th Edition, is an ideal resource for pathologists in training and in practice. High-quality illustrations with extensive figure legends depict the histological, immunohistochemical, cytologic and diagnostic imaging appearances of every type of head and neck pathology, while the user-friendly format allows for quick access to information. From cover to cover, this comprehensive reference is designed to help you effectively and accurately diagnose a wide range of head and neck disorders, improve your turnaround time when diagnosing a specimen, and facilitate clear reports on prognosis and therapeutic management options to surgical and medical colleagues. 

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Cover image

Title page

Table of Contents

Dedication

Copyright

In Memoriam

Preface

Section 1. Nasal Cavity and Paranasal Sinuses

Section 1. Nasal Cavity and Paranasal Sinuses

Chapter 1. Embryology, Anatomy, and Histology of the Sinonasal Tract

Nasal Cavity

Paranasal Sinuses

Chapter 2. Nonneoplastic Lesions of the Sinonasal Tract

Classification of Nonneoplastic Lesions of the Sinonasal Tract (Box 2.1)

Infectious-Related Diseases of the Sinonasal Tract

Noninvasive FRS

Invasive Fungal Sinusitis (Figs. 2.40 and 2.41)

Other Fungi (Fig. 2.48)

Bacterial Infections

Miscellaneous Sinonasal Bacterial Infections

Protozoal Nasal Infections

Viral Infection

Sarcoidosis

Myospherulosis (Fig. 2.53)

Extranodal Rosai-Dorfman Disease (ERDD) (Fig. 2.54)

Granulomatosis With Polyangiitis (GPA) (Figs. 2.55–2.58)

Eosinophilic Angiocentric Fibrosis (EAF) (Fig. 2.60)

IgG4-Related Diseases

Necrotizing Sialometaplasia (NS)

Chapter 3. Neoplasms of the Sinonasal Tract

Classification of Neoplasms of the Sinonasal Tract (Box 3.1)

Benign Neoplasms

Fibromatosis/Extraabdominal Fibromatoses

Malignant Neoplasms of the Nasal Cavity and Paranasal Sinuses

Rhabdomyosarcoma (RMS)

Section 2. Oral Cavity

Section 2. Oral Cavity

Chapter 4. Embryology, Anatomy, and Histology of the Oral Cavity

Embryology

Contents (Fig. 4.1)

Anatomic Borders

Innervation

Vascular Supply and Lymphatic Drainage

Chapter 5. Nonneoplastic Lesions of the Oral Cavity

Classification of Nonneoplastic Lesions of the Oral Cavity (Box 5.1)

Cystic (Nonneoplastic) Lesions

Infectious Diseases

Reactive, Inflammatory, and Tumor-Like Lesions of the Oral Cavity

Nonneoplastic Osseous-Related Lesions of the Head and Neck

Selective Autoimmune, Allergic, Systemic, Cutaneous-Type, and Miscellaneous Diseases Affecting the Oral Cavity

Chapter 6. Neoplasms of the Oral Cavity

Benign Neoplasms

Premalignant Oral Diseases/Lesions

Chapter 7. Intraoperative Consultation in Oral Cavity Mucosal Lesions

Indications

Surgeon’s Expectations

Specimen Handling and Orientation (Figs. 7.1 and 7.2)

Right-Angle (Perpendicular) Versus Parallel (En Face) Sections

Surgical Resection Margins

Differential Diagnosis or Pitfalls in the Intraoperative Assessment of Squamous Cell Carcinoma, Including Intraepithelial Dysplasia and Invasive Carcinoma

Contraindications (Fig. 7.11)

Intraoperative “Rapid” Immunohistochemical Assessment

Molecular Biology in the Assessment of Surgical Margins (Molecular Margins of Resection)

Accuracy

Lymph Nodes

Section 3. Pharynx, Including Nasopharynx, Oropharynx, and Hypopharynx

Section 3. Pharynx, Including Nasopharynx, Oropharynx, and Hypopharynx

Chapter 8. Embryology, Anatomy, and Histology of the Pharynx

Pharynx

Histology

Chapter 9. Nonneoplastic Lesions of the Pharynx

Classification of Nonneoplastic Lesions of the Pharynx (Box 9.1)

Nasopharyngeal Cysts

Pharyngeal Hamartomas, Choristomas, and Teratomatous Lesions

Infectious Diseases

Viral Diseases

Fungi

Bacteria and Spirochetes

Protozoa (Fig. 9.21)

Tangier Disease (Fig. 9.22)

Chapter 10. Neoplasms of the Pharynx

Neoplasms of the Pharynx (Box 10.1)

Malignant Tumors

Section 4. The Neck

Section 4. The Neck

Chapter 11. Anatomy of the Neck

Anatomy (Fig. 11.1)

Chapter 12. Nonneoplastic Lesions of the Neck

Classification of Nonneoplastic Lesions of the Neck (Box 12.1)

Benign Cystic Lesions of the Cervical Neck

Mycobacterial and Other Granulomatous Diseases

Bacterial Diseases

Chapter 13. Neoplasms of the Neck

Classification of Neoplasms of the Neck (Box 13.1)

Surgical Specimens

Borderline or Intermediate Fibroblastic/Myofibroblastic Tumors

Malignant Tumors

Evaluation of Posttreated Neck for Metastatic Carcinoma (Fig. 13.60)

Secondary Tumors to the Neck (Other Than Carcinoma From Head and Neck Sites)

Section 5. Larynx and Trachea

Section 5. Larynx and Trachea

Chapter 14. Embryology, Anatomy, and Histology of the Larynx and Trachea

Larynx

Hypopharynx

Trachea

Chapter 15. Nonneoplastic Lesions of the Larynx and Trachea

Classification of Nonneoplastic Lesions of the Larynx and Trachea (Box 15.1)

Acquired and Congenital Lesions

Laryngocele and Laryngeal Cysts

Chapter 16. Neoplasms of the Larynx and Trachea

Classification of NEOPLASMS of the Larynx and Trachea (Box 16.1)

Benign Neoplasms of the Larynx

Benign Salivary Gland Tumors

Benign Nonepithelial Tumors

Malignant Neoplasms

Laryngeal Intraepithelial Dysplasia

Laryngeal Carcinoma In Situ (CIS) (Fig. 16.22)

Microinvasive Carcinoma (Figs. 16.23–16.26)

Laryngeal Invasive Squamous Cell Carcinoma (Figs. 16.27–16.31)

Variants of Squamous Cell Carcinoma (Box 16.4)

Other Uncommon Carcinoma Variants

Laryngeal Salivary Gland Malignant Neoplasms

Laryngeal Neuroendocrine Neoplasms

Laryngeal Neuroendocrine Neoplasms (See Box 16.5)

Laryngeal Neuroendocrine Carcinomas

Nonepithelial Malignant Neoplasms of the Larynx

Chapter 17. Intraoperative Consultation of Laryngeal and Tracheal Lesions

Indications

Surgeon Expectations

Specimen Handling and Orientation

Definition of a “Positive” Margin

Adequacy of Resection Margins

Section 6. Major and Minor Salivary Glands

Section 6. Major and Minor Salivary Glands

Chapter 18. Embryology, Anatomy, and Histology of the Salivary Glands

Embryology

Anatomic Borders (Fig. 18.1)

Innervation

Histology (Figs. 18.2–18.5; Tables 18.1 and 18.2)

Chapter 19. Nonneoplastic Diseases of Salivary Glands

Classification of Nonneoplastic Salivary Gland Lesions (Box 19.1)

Developmental Lesions

Hyperplasia and Metaplasia

True Nonneoplastic Cysts of Major Salivary Glands (Sialocysts)

Nondevelopmental Cysts

Infectious, Inflammatory, Autoimmune Lesions of Salivary Glands

Chapter 20. Neoplasms of the Salivary Glands

Classification of Neoplasms of Salivary Glands (Box 20.1)

Benign Neoplasms

Basal Cell Adenoma (BCA)(Figs. 20.19–20.25)

Warthin Tumor (WT) (Figs. 20.26–20.32)

Canalicular Adenoma (CA)(Figs. 20.33–20.35)

Oncocytoma (Fig. 20.36)

Myoepithelioma (Figs. 20.37–20.41)

Cystadenoma (Fig. 20.42)

Ductal Papillomas

Other Uncommon Benign Epithelial Neoplasms

Tumors With Sebaceous Differentiation

Benign Soft Tissue Tumors

Malignant Neoplasms

Polymorphous Adenocarcinoma Classification—Genotypic-Phenotypic Correlation

Malignant Mixed Tumors of Salivary Glands

Cystadenocarcinoma (Figs. 20.145–20.148)

Microsecretory Adenocarcinoma (Figs. 20.149 and 20.150)

Sclerosing Microcystic Adenocarcinoma (Fig. 20.151)

Mucinous Adenocarcinoma (Fig. 20.152)

Adenocarcinoma, Not Otherwise Specified (Figs. 20.153–20.157)

Primary Squamous Cell Carcinoma (SCC) (Figs. 20.158 and 20.159)

Lymphoepithelial Carcinoma (LEC) (Figs. 20.160 and 20.161)

Neuroendocrine Neoplasms

Malignant Sebaceous Tumors

Nonepithelial Malignant Salivary Gland Tumors

Sarcomas of Salivary Glands

Secondary Tumors

Chapter 21. Intraoperative Consultation in Salivary Glands and Biopsy Diagnosis of Salivary Gland Neoplasms

Intraoperative Consultation in Salivary Glands (Figs. 21.1–21.13)

Indications for Intraoperative Consultation in Salivary Gland Neoplasms

Surgeon’s Expectations of the Intraoperative Assessment of Salivary Gland Neoplasms

Approach to Handling of Resected Tissue

Diagnostic Considerations

Accuracy of Intraoperative Diagnosis

Biopsy Diagnosis of Salivary Gland Neoplasms (Figs. 21.14 to 21.19)

CONCLUSIONS

Section 7. External, Middle, and Internal Ear

Section 7. External, Middle, and Internal Ear

Chapter 22. Embryology, Anatomy, and Histology of the Ear

Embryology

Anatomy (Figs. 22.1 to 22.3)

Eustachian (Auditory) Tube

Innervation

Blood Supply and Lymphatic Drainage

Histology (Fig. 22.4)

Auditory Epithelial Migration

Middle Ear (Figs. 22.5 and 22.6)

Chapter 23. Nonneoplastic Lesions of the Ear and Temporal Bone

Classification of Nonneoplastic Lesions of the Ear (Box 23.1)

Congenital and Developmental Abnormalities of the Ear

External Ear

Middle and Inner Ear

Heterotopias (Choristomas) of the Middle Ear and Mastoid

Acquired Lesions of the Ear

Middle Ear and Temporal Bone

Infectious and Inflammatory Lesions

Otitis Media (Figs. 23.24 to 23.27)

Autoimmune, Systemic, and Degenerative Diseases of the Ear

Tophaceous Gout (Figs. 23.34 and 23.35)

Granulomatosis With Polyangiitis (GPA) (See Chapter 2)

Otosclerosis (Fig. 23.38)

Paget Disease of Bone (Figs. 23.39 and 23.40)

Ménière Disease

Chapter 24. Neoplasms of the Ear and Temporal Bone

Classification of Neoplasms of the Ear (Box 24.1)

Benign Neoplasms of the Middle Ear and Temporal Bone

Malignant Neoplasms of the External Ear

Malignant Neoplasms of the Middle Ear

Other Malignant Tumors of the Middle Ear and Temporal Bone

Chapter 25. Immunohistochemistry of Middle Ear Neoplasms

Section 8. Thyroid Gland

Section 8. Thyroid Gland

Chapter 26. Embryology, Anatomy, Histology, and Physiology of the Thyroid Gland

Embryology (Fig. 26.1)

Anatomy (Fig. 26.2)

Vascular Supply and Lymphatics

Histology

Thyroid C Cells (Fig. 26.6)

Chapter 27. Nonneoplastic Lesions of the Thyroid Gland

Classification of Nonneoplastic Lesions of the Thyroid Gland ( Box 27.1)

Ovarian Thyroid Tissue (Figs. 27.16–27.18)

Metaplasia of Thyroid Follicular Epithelium

Mesenchymal-Derived “Inclusions” in the Thyroid Gland

Hypothyroidism and Hyperthyroidism

Nonautoimmune Thyroiditis

Chapter 28. Neoplasms of the Thyroid Gland

CLASSIFICATION OF NEOPLASMS OF THE THYROID GLAND (BOX 28.1)

MOLECULAR GENETICS OF FOLLICULAR CELL–DERIVED THYROID TUMORS (TABLE 28.7)

MOLECULAR DICHOTOMY

CLINICAL STAGING OF THYROID CARCINOMA

Benign Follicular Epithelial Neoplasms

HISTOLOGIC TYPES OF FOLLICULAR THYROID ADENOMA CLASSIFIED BY CELL TYPE OR GROWTH PATTERN (BOX 28.3)

LOW-RISK FOLLICULAR CELL–DERIVED NEOPLASMS

NONINVASIVE FOLLICULAR THYROID NEOPLASM WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP) (FIGS. 28.24–28.28)

MALIGNANT FOLLICULAR EPITHELIAL AND C CELL–DERIVED NEOPLASMS

PAPILLARY THYROID CARCINOMA (PTC)

HISTOLOGIC TYPES OF PTC (BOX 28.6)

FOLLICULAR VARIANT OF PAPILLARY THYROID CARCINOMA (FVPTC)

HIGH-GRADE FOLLICULAR CELL–DERIVED NONANAPLASTIC THYROID CARCINOMAS

UNUSUAL EPITHELIAL TUMORS OF THE THYROID GLAND

Neuroendocrine Neoplasms

C CELL–RELATED LESIONS (C CELL HYPERPLASIA AND MEDULLARY THYROID CARCINOMA)

Lymphoproliferative Diseases of the Thyroid Gland

MALIGNANT LYMPHOPROLIFERATIVE NEOPLASMS

Nonepithelial Neoplasms of the Thyroid, Excluding Lymphoproliferative Diseases

THYROID LESIONS WITH THYMIC DIFFERENTIATION

INTRATHYROID THYMIC CARCINOMA OR CARCINOMA SHOWING THYMUS-LIKE DIFFERENTIATION (CASTLE) (FIG. 28.130)

SECONDARY OR METASTATIC TUMORS TO THE THYROID GLAND (FIGS. 28.132–28.134)

Chapter 29. Thyroid Gland Post–Fine Needle Aspiration Biopsy–Related Histologic Changes and Intraoperative Consultation

Post–Fine Needle Aspiration Biopsy (FNAB)–Related Morphologic Changes (Figs. 29.1–29.12)

Surgeon’s Expectations

Intraoperative Cytology

Summary

Section 9. Parathyroid Glands

Section 9. Parathyroid Glands

Chapter 30. Embryology, Anatomy, and Histology of the Parathyroid Glands

Embryology

Anatomic Considerations (Fig. 30.1)

Histology (Figs. 30.2–30.4; Table 30.1)

Chapter 31. General Considerations

Hyperparathyroidism

Hypoparathyroidism

Chapter 32. Nonneoplastic Lesions of the Parathyroid Glands

Classification of Nonneoplastic Lesions of the Parathyroid Glands (Box 32.1)

Primary Chief Cell Hyperplasia (Figs. 32.1–32.5; Table 32.1)

Water–Clear-Cell Hyperplasia (Fig. 32.6)

Secondary Hyperparathyroidism

Tertiary Hyperparathyroidism

Parathyromatosis (Fig. 32.8)

Parathyroid Cyst (Figs. 32.9–32.11)

Chronic Parathyroiditis (Fig. 32.12)

Chapter 33. Neoplasms of the Parathyroid Glands

Classification of Neoplasms of the Parathyroid Glands (Box 33.1)

Chapter 34. Intraoperative Consultation (Frozen Section) in Parathyroid Gland and Parathyroid Proliferative Disease/Hyperparathyroidism

Considerations

Normal Size and Weight (Table 34.1)

Indications for Intraoperative Consultation for Hyperparathyroidism

Surgeons’ Expectations of the Intraoperative Assessment of Parathyroid Exploration

Practical Reality of the Intraoperative Assessment of Parathyroid Exploration

Handling of Resected Parathyroid Glands

Inking of Parathyroid Glands

Microscopic Findings on Frozen Section

Microhyperplasia

FlowChart for Intraoperative Assessment for Hyperparathyroidism

Pitfalls and/or Issues in the Intraoperative Evaluation of Parathyroid Glands

Reexploration for Persistent or Recurrent Hyperparathyroidism

Parathyroid Carcinoma

Parathyroid Proliferative Disease in “Ectopic” Sites

Adjunct Methods in the Intraoperative Evaluation of PPD

Intraoperative Monitoring of Parathyroid Hormone Levels

Accuracy of Intraoperative Confirmation of Parathyroid Tissue and Intraoperative Diagnosis

Section 10. Multiple Endocrine Neoplasia (MEN) Syndromes

Section 10. Multiple Endocrine Neoplasia (MEN) Syndromes

Chapter 35. Multiple Endocrine Neoplasia Syndromes and Selective Inherited Syndromes With Associated Endocrine Neoplasms

MEN Type 1

MEN Type 2

Familial Medullary Thyroid Carcinoma (FMTC)

MEN Type 4

MEN 5 (MAX-Related Tumors)

Selective Inherited Syndromes With Different Endocrine Neoplasms

Index

OPINIA CITITORILOR